Fetal Hydantoin Syndrome

Fetal hydantoin syndrome: A case report.

Fetal hydantoin syndrome (FHS) is a spectrum of defects caused to the developing fetus by exposure to the teratogenic effects of antiepileptic drug (AED) phenytoin during pregnancy. Its clinical manifestations include limb abnormalities, ocular defects, central nervous system anomalies, intrauterine growth restriction, and hand and phalangeal anomalies. This case report presents an 8-year-old c...

Expanding Phenotype of Fetal Hydantoin

subsequent birth of normal children occur frequently enough to be frustrating for those involved in the evaluation of malformed children and counseling of the parents. The fetal hydantoin syndrome, while a recognizable pattern of malformation in some patients,2 is not such a well defined entity as, for example, achondroplasia or Down syndrome is. It is not uncommon for one to see a child with s...

Fetal Hydantoin Syndrome and Its Anaesthetic Implications: A Case Report

Fetal hydantoin syndrome is a rare disorder that is believed to be caused by exposure of a fetus to the anticonvulsant drug phenytoin. The classic features of fetal hydantoin syndrome include craniofacial anomalies, prenatal and postnatal growth deficiencies, underdeveloped nails of the fingers and toes, and mental retardation. Less frequently observed anomalies include cleft lip and palate, mi...

Discordant expression of fetal hydantoin syndrome in heteropaternal dizygotic twins.

Decreased ornithine decarboxylase in the fetal hydantoin syndrome.

The anticonvulsant diphenylhydantion (DPH) causes embryonic folate antagonism in the animal model of the fetal hydantoin syndrome. Thus, comparisons were made between the metabolic effects of the teratogens DPH and 9-methyl pteroylglutamic acid (9-methyl PGA), a folate antagonist. The DPH inhibited ornithine decarboxylase (ODC), the rate-limiting enzyme in putrescine biosynthesis, and caused re...